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Ivabradine in Management of Heart Failure: a Critical Appraisal

Gabriela Orasanu1, Sadeer G Al-Kindi1, Guilherme H Oliveira2

  • 1Advanced Heart Failure and Transplantation Center, Harrington Heart & Vascular Institute, Department of Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106, USA.

Current Heart Failure Reports
|January 23, 2016
PubMed

Insights

Ivabradine effectively lowers heart rate in chronic systolic heart failure patients. This medication is approved for specific heart failure (HF) patients with elevated resting heart rate (HR) to improve outcomes.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Elevated resting heart rate (HR) is associated with adverse outcomes in chronic systolic heart failure.
  • The funny current channel (If) plays a role in regulating cardiac rhythm.

Purpose of the Study:

  • To review and evaluate the efficacy of ivabradine in heart failure (HF) patients.
  • To explore the mechanisms and physiological effects of ivabradine.

Main Methods:

  • Review of clinical trial data and pharmacological studies on ivabradine.
  • Analysis of ivabradine's impact on heart rate and clinical outcomes in HF populations.

Main Results:

  • Ivabradine selectively blocks the funny current channel, reducing heart rate without affecting contractility.
  • Clinical trials demonstrate ivabradine's benefit in stable, symptomatic chronic HF patients with specific criteria (LVEF ≤35%, HR ≥70 bpm).

Conclusions:

  • Ivabradine is a valuable therapeutic option for selected heart failure patients.
  • The drug offers heart rate reduction and potential outcome improvement in HF management.

Keywords:
Funny channelHeart failureHeart rateHospitalizationInhibitorIvabradine

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