Related Experiment Video

Updated: Mar 26, 2026

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
03:47

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography

Published on: November 1, 2024

434

Behcet's Disease: Is There Geographical Variation? A Review Far from the Silk Road

Nieves Marie Leonardo1, Julian McNeil1

  • 1Department of Rheumatology, Modbury Hospital, Smart Road, Modbury, SA 5092, Australia; Discipline of Medicine, Faculty of Health Sciences, University of Adelaide, Modbury Hospital, Modbury, SA, Australia.

International Journal of Rheumatology
|January 23, 2016
PubMed

Insights

Behcet

Area of Science:

  • Rheumatology
  • Immunology
  • Systemic Vasculitis

Background:

  • Behcet's Disease (BD) is a systemic vasculitis.
  • Characterized by recurrent oral and genital ulcers, and eye inflammation.
  • Diagnosis relies on clinical presentation due to lack of specific lab tests.

Purpose of the Study:

  • To highlight diagnostic challenges in Behcet's Disease.
  • To discuss geographical variations in clinical manifestations.
  • To emphasize the importance of recognizing evolving symptoms for timely diagnosis.

Main Methods:

  • Clinical observation and case reviews.
  • Analysis of diagnostic criteria and their limitations.
  • Review of geographical variations in disease presentation.

Main Results:

  • Diagnosis is often delayed as symptoms manifest over time.
  • Geographical variations exist, with differing frequencies of cardiac and neurological involvement.
  • Current diagnostic criteria may not capture all cases.

Conclusions:

  • Behcet's Disease diagnosis requires careful, long-term clinical evaluation.
  • Awareness of geographical differences in manifestations is crucial for accurate diagnosis and management.
  • Immunosuppressive and immunomodulatory therapies are standard treatments.

More Related Videos

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK07:27

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

Published on: December 18, 2012

12.5K
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

11.2K

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
901
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.5K
Genetic Lingo01:11

Genetic Lingo

Overview
117.6K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
109
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
28
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.4K