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Related Concept Videos

Classification of Leukocytes01:30

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The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
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Related Experiment Video

Updated: Mar 26, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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[Classification of malignant lymphomas. Current situation].

K Koch1, W Klapper2

  • 1Institut für Pathologie, Sektion Hämatopathologie und Lymphknotenregister, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, Haus 14, 24113, Kiel, Deutschland. karoline.koch@uksh.de.

Der Internist
|January 24, 2016
PubMed
Summary
This summary is machine-generated.

The World Health Organization (WHO) is updating its malignant lymphoma classification. New findings in diagnostics, including early lesions and genetic mutations, are incorporated for better subclassification and patient outcomes.

Keywords:
BRAF protein, humanIn situ lymphomaLymphoma, T-cell, peripheralLymphoma, large B-cell, diffuseMYD88 protein

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • The World Health Organization (WHO) is preparing to update the classification of malignant lymphomas.
  • This update reflects recent advancements in understanding these hematologic malignancies.

Purpose of the Study:

  • To present novel findings relevant to the diagnosis and subclassification of malignant lymphomas.
  • To highlight emerging entities and prognostic subgroups within lymphoma classification.

Main Methods:

  • A comprehensive literature search was conducted using PubMed (ncbi.nlm.nih.gov).
  • Findings were integrated with the authors' clinical and pathological diagnostic expertise.

Main Results:

  • Recent literature describes an increasing number of early malignant lymphoma lesions, though their malignancy potential remains uncertain for some.
  • New entities within T-cell lymphomas have been defined, and prognostic subgroups identified in diffuse large B-cell lymphomas.
  • Mutation detection is emerging as a key tool for differentiating morphologically similar diseases.

Conclusions:

  • Current scientific discoveries are increasingly influencing lymphoma diagnostics.
  • The forthcoming WHO classification update is a direct result of these evolving insights.