Related Experiment Video
Updated: Mar 26, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
HEART Pathway Accelerated Diagnostic Protocol Implementation: Prospective Pre-Post Interrupted Time Series Design and
Simon A Mahler1, Gregory L Burke, Pamela W Duncan
1Wake Forest School of Medicine, Department of Emergency Medicine, Winston Salem, NC, United States. smahler@wakehealth.edu.
Insights
The HEART Pathway (History/ECG/Age/Risk Factors/Troponin) accelerates chest pain diagnosis, safely reducing hospitalizations and length of stay for emergency department patients. This protocol identifies suitable candidates for early discharge, improving healthcare efficiency.
Area of Science:
- Cardiology
- Emergency Medicine
- Health Services Research
Background:
- Chest pain evaluations in US Emergency Departments (ED) are costly (>$10 billion annually) with low diagnostic yield (<10%) for acute coronary syndrome (ACS).
- The HEART Pathway (History/ECG/Age/Risk Factors/Troponin) is an accelerated diagnostic protocol (ADP) designed for early ED discharge of low-risk chest pain patients.
- Prior studies indicate the HEART Pathway safely reduces cardiac testing and hospitalizations.
Purpose of the Study:
- To determine the effectiveness of implementing the HEART Pathway ADP within a health system.
- To evaluate the impact of the HEART Pathway on healthcare utilization and patient outcomes.
Main Methods:
- A controlled before-after study involving approximately 10,000 adult patients with acute chest pain (excluding STEMI) over two years.
- Outcome measures include hospitalization rates, objective cardiac testing (stress tests, angiography), length of stay, and recurrent cardiac care rates.
- The HEART Pathway was integrated into electronic medical records for real-time provider decision support.
Main Results:
- Pilot data showed a 21% reduction in hospitalizations and a median 12-hour reduction in hospital length of stay.
- No increase in adverse events or recurrent cardiac care was observed.
- Over 5000 patient encounters have been analyzed, with full electronic health record integration.
Conclusions:
- The HEART Pathway is hypothesized to safely reduce healthcare utilization for acute chest pain patients.
- This ADP offers a model for high-value care delivery to millions of US ED patients annually.
- Implementation demonstrates successful integration and potential for widespread adoption.
Background:
Most patients presenting to US Emergency Departments (ED) with chest pain are hospitalized for comprehensive testing. These evaluations cost the US health system >$10 billion annually, but have a diagnostic yield for acute coronary syndrome (ACS) of <10%. The history/ECG/age/risk factors/troponin (HEART) Pathway is an accelerated diagnostic protocol (ADP), designed to improve care for patients with acute chest pain by identifying patients for early ED discharge. Prior efficacy studies demonstrate that the HEART Pathway safely reduces cardiac testing, while maintaining an acceptably low adverse event rate.
Objective:
The purpose of this study is to determine the effectiveness of HEART Pathway ADP implementation within a health system.
Methods:
This controlled before-after study will accrue adult patients with acute chest pain, but without ST-segment elevation myocardial infarction on electrocardiogram for two years and is expected to include approximately 10,000 patients. Outcomes measures include hospitalization rate, objective cardiac testing rates (stress testing and angiography), length of stay, and rates of recurrent cardiac care for participants.
Results:
In pilot data, the HEART Pathway decreased hospitalizations by 21%, decreased hospital length (median of 12 hour reduction), without increasing adverse events or recurrent care. At the writing of this paper, data has been collected on >5000 patient encounters. The HEART Pathway has been fully integrated into health system electronic medical records, providing real-time decision support to our providers.
Conclusions:
We hypothesize that the HEART Pathway will safely reduce healthcare utilization. This study could provide a model for delivering high-value care to the 8-10 million US ED patients with acute chest pain each year.
Clinicaltrial:
Clinicaltrials.gov NCT02056964; https://clinicaltrials.gov/ct2/show/NCT02056964 (Archived by WebCite at http://www.webcitation.org/6ccajsgyu).
More Related Videos
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
04:24A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
Published on: April 19, 2019
Related Concept Videos
Acute Coronary Syndrome III: Diagnostic Studies
Cardiac Catheterization I: Pre-Procedure Overview
Pulse rhythm
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...