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Published on: September 19, 2016
Circulating soluble receptor for advanced glycation end products is decreased and inversely associated with acute
A Kasperska-Zajac1, A Damasiewicz-Bodzek2, K Tyrpień-Golder2
1Department of Internal Diseases, Dermatology and Allergology in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. M. Curie-Skłodowskiej 10, 41-800, Zabrze, Poland. alakasperska@gmail.com.
Background:
Activation of receptor for advanced glycation end products (RAGE) leads to the proinflammatory response and the release of its soluble form (sRAGE) which appears to function as an anti-inflammatory feedback mechanism.
Aim:
To determine serum sRAGE concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity.
Methods:
Concentrations of sRAGE and CRP were measured in serum of CSU patients and compared with the healthy controls.
Results:
Serum sRAGE concentrations were significantly decreased in CSU patients, especially those more severely affected. In addition, significant inverse correlations were observed between sRAGE and CRP concentrations.
Conclusions:
Down-regulation of sRAGE and its association with acute phase response suggest a role for RAGE activation in the pathogenesis of CSU. It seems that lower serum sRAGE concentration may enhance the urticarial processes.
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