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Updated: Mar 26, 2026

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Nausea and Vomiting During Pregnancy is Highly Heritable.

Lucía Colodro-Conde1,2, Patrick Jern3,4, Ada Johansson5,3,4

  • 1Quantitative Genetics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia. lucia.colodroconde@qimrberghofer.edu.au.

Behavior Genetics
|January 24, 2016
PubMed
Summary

Genetic factors significantly influence nausea and vomiting during pregnancy (NVP). This study found high heritability for NVP presence, duration, and severity, highlighting the role of genetics.

Keywords:
HeritabilityMorning sicknessNVP Genetics ConsortiumNausea and vomiting during pregnancyTwin studyWomen’s health

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Area of Science:

  • Reproductive Health
  • Human Genetics
  • Psychosomatic Medicine

Background:

  • Nausea and vomiting during pregnancy (NVP) affects up to 70% of expectant mothers.
  • NVP significantly impacts physical health and psychosocial functioning.
  • Understanding the etiology of NVP is crucial for developing effective interventions.

Purpose of the Study:

  • To estimate the heritability of the presence, duration, and severity of NVP.
  • To investigate the genetic and environmental influences on NVP.
  • To identify potential genetic variants contributing to NVP.

Main Methods:

  • Utilized an extended twin design with 1723 women from the NVP Genetics Consortium.
  • Included complete and incomplete twin pairs and their sisters.
  • Applied OpenMx and Mx software for secondary analysis of NVP traits.

Main Results:

  • Heritability estimates for NVP presence were 73%, duration 51%, and severity 53%.
  • Additive genetic and unique environmental effects best explained individual differences in NVP.
  • A near-perfect genetic correlation was observed between NVP duration and severity.

Conclusions:

  • Genetic factors play a substantial role in the presence, duration, and severity of NVP.
  • The findings support the importance of investigating genetic variants underlying NVP.
  • This research provides a foundation for future genetic studies on NVP.