Related Experiment Video

Updated: Mar 26, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

807

Another Preemie with Hypoglycemia? Beckwith-Wiedemann Syndrome--A Case Study

Polli Tower, Veeral N Tolia

    Neonatal Network : NN
    |January 24, 2016
    PubMed

    Insights

    Beckwith-Wiedemann syndrome (BWS), a common infant overgrowth disorder, was diagnosed in a premature infant with an unusual presentation at one month old. The review covers BWS etiology, diagnosis, and management strategies.

    Area of Science:

    • Pediatric endocrinology
    • Clinical genetics

    Background:

    • Beckwith-Wiedemann syndrome (BWS) is the most frequent congenital imprinting disorder associated with overgrowth.
    • Early diagnosis and management are crucial for improving outcomes in affected infants.

    Observation:

    • A case of a premature infant presenting with atypical features of BWS is reviewed.
    • Diagnosis was established at one month of age, highlighting diagnostic challenges in preterm infants.

    Findings:

    • The article details the etiology, emphasizing genetic and epigenetic factors contributing to BWS.
    • Diagnostic criteria and methods for identifying BWS in neonates and infants are discussed.
    • Management strategies focus on monitoring for common BWS complications, including tumors and metabolic issues.

    Implications:

    • This review provides insights into the atypical presentation of BWS in premature infants.
    • It underscores the importance of considering BWS in the differential diagnosis of overgrowth disorders, even with unusual clinical features.
    • Understanding the nuances of BWS etiology and management can guide clinical practice and improve patient care.

    More Related Videos

    Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test06:59

    Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

    Published on: November 13, 2016

    11.5K
    Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

    Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

    Published on: November 20, 2015

    12.0K

    Related Concept Videos

    Inborn Errors of Metabolism01:20

    Inborn Errors of Metabolism

    Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
    1.0K
    Hypoglycemia and Glucagon01:15

    Hypoglycemia and Glucagon

    Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
    1.3K
    Pathophysiology of Diabetes01:20

    Pathophysiology of Diabetes

    Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
    Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
    4.3K
    Glucose Transporters01:27

    Glucose Transporters

    Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
    Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
    28.2K
    Diabetes Mellitus: Type 2 and Gestational01:22

    Diabetes Mellitus: Type 2 and Gestational

    Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
    5.5K
    Diabetes Mellitus: Overview and Type I Subtype01:22

    Diabetes Mellitus: Overview and Type I Subtype

    Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
    Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
    5.9K