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Updated: Mar 26, 2026

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
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HIV-1 Envelope Under Attack.

Wei Wei1, Xiao-Fang Yu1

  • 1First Hospital of Jilin University, Institute of Virology and AIDS Research, Changchun, Jilin Province, China; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.

Trends in Microbiology
|January 25, 2016
PubMed
Summary
This summary is machine-generated.

The human immunodeficiency virus type 1 (HIV-1) envelope protein is blocked from viral particles by a host factor called membrane-associated-RING-CH8 (MARCH8). This discovery adds MARCH8 to known factors that combat HIV-1.

Keywords:
HIV-1MARCH8envelope glycoproteinvirion incorporation

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Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging
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Last Updated: Mar 26, 2026

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Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging
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Determination of Molecular Structures of HIV Envelope Glycoproteins using Cryo-Electron Tomography and Automated Sub-tomogram Averaging

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Area of Science:

  • Virology
  • Immunology
  • Cell Biology

Background:

  • The human immunodeficiency virus type 1 (HIV-1) envelope (Env) is crucial for viral replication.
  • HIV-1 Env is a key target for host antiviral mechanisms.

Purpose of the Study:

  • To identify host factors that restrict HIV-1 replication.
  • To investigate the role of membrane-associated-RING-CH8 (MARCH8) in controlling HIV-1 Env.

Main Methods:

  • Investigated the antiviral activity of MARCH8 against HIV-1.
  • Assessed the effect of MARCH8 on the incorporation of HIV-1 Env into virions.

Main Results:

  • Identified membrane-associated-RING-CH8 (MARCH8) as a potent inhibitor of HIV-1.
  • MARCH8 blocks the incorporation of HIV-1 Env into viral particles.

Conclusions:

  • MARCH8 is a host antiviral factor that targets HIV-1 Env.
  • MARCH8 represents a novel host defense mechanism against HIV-1.