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Updated: Mar 26, 2026
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
Association between human leukocyte antigen class II and pulmonary tuberculosis due to mycobacterium tuberculosis in
Dan Wamala1,2, Helen Koyokoyo Buteme3,4, Samuel Kirimunda4
1Department of Pathology, Mulago Hospital and Makerere University, Kampala, Uganda. dwamala@gmail.com.
Background:
Mycobacterium tuberculosis (Mtb) is reported to infect about a third of the world's population but only 10% are thought to develop active tuberculosis (TB) disease. Host immunity regulated by human leukocyte antigens (HLA) is an important determinant of the outcome of the disease. Here we investigate HLA class II gene polymorphisms in susceptibility to TB, and whether particular HLA class II alleles were associated with TB in Uganda.
Methods:
HIV negative patients with pulmonary TB (n = 43) and genetically related healthy household controls (n = 42) were typed for their HLA II class alleles using polymerase chain reaction sequence specific primer amplification.
Results:
The HLA-DQB1*03:03 allele was significantly less frequent in patients compared to healthy controls (10% in controls versus 0% in patients, p = 0.003). After correction for multiple comparisons the difference remained significant (p = 0.018).
Conclusions:
Our results suggest that the HLA-DQB1*03:03 allele may be associated with resistance to TB.
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