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Intrathecal Sufentanil Does Not Reduce Shivering During Neuraxial Anesthesia: A Meta-Analysis
Lin Shao Feng1, Gao Hong2, Zhao Yan3
1Department of Anesthesiology, Guizhou Medical University, Guiyang, Guizhou, China (mainland).
Summary
Intrathecal sufentanil did not effectively prevent shivering during neuraxial anesthesia. However, it significantly increased the incidence of pruritus, a common side effect, while reducing vomiting.
Area of Science:
- Anesthesiology and Pain Management
- Pharmacology
- Clinical Trials
Background:
- Shivering is a common complication during neuraxial anesthesia.
- Intrathecal sufentanil is sometimes used to prevent shivering.
- The efficacy and safety of intrathecal sufentanil for this purpose require evaluation.
Purpose of the Study:
- To evaluate the efficacy of intrathecal sufentanil in preventing shivering during neuraxial anesthesia.
- To assess the incidence of shivering and related complications with intrathecal sufentanil use.
Main Methods:
- Meta-analysis of randomized controlled trials (RCTs).
- Searched Cochrane Library, PubMed, and Embase for relevant studies.
- Evaluated study quality and performed statistical analysis using RevMan 5.3.
Main Results:
- Eight RCTs involving 1032 patients were analyzed.
- Intrathecal sufentanil did not significantly reduce shivering incidence (P=0.06).
- It significantly increased pruritus (P<0.00001) but reduced vomiting (P=0.03). No significant increase in nausea, hypotension, or bradycardia.
Conclusions:
- Intrathecal sufentanil is not effective in preventing shivering during neuraxial anesthesia.
- Increased incidence of pruritus is a notable side effect.
- The drug may reduce vomiting incidence.
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