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Related Experiment Video

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A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors

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Insight into SUCNR1 (GPR91) structure and function.

Julie Gilissen¹, François Jouret², Bernard Pirotte³

¹Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, Liège, Belgium; Laboratory of Medicinal Chemistry, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, Belgium.

Pharmacology & Therapeutics

|January 26, 2016

Summary

Succinate receptor 1 (SUCNR1) is a G protein-coupled receptor activated by succinate. This review explores SUCNR1

Keywords:

Diabetes GPR91 Hypertension Ischemia–reperfusion injury SUCNR1 Succinate

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Area of Science:

Biochemistry
Molecular Biology
Pharmacology

Background:

G protein-coupled receptors (GPCRs) are a major drug target class.
SUCNR1, initially an orphan receptor, is activated by succinate, a metabolic intermediate.
Succinate signaling via SUCNR1 is implicated in cellular stress and metabolism.

Purpose of the Study:

To review the structural features, ligands, and signaling pathways of SUCNR1.
To discuss the pathophysiological roles of SUCNR1 in various diseases.
To highlight SUCNR1 as a potential drug target for novel therapeutics.

Main Methods:

Literature review of structural and functional studies on SUCNR1.
Analysis of in vitro and in vivo data on SUCNR1 signaling.
Discussion of the link between SUCNR1 pathways and disease.

Main Results:

SUCNR1 is activated by succinate, influencing cellular metabolism and stress responses.
SUCNR1 is involved in hypertension, inflammation, and angiogenesis.
Its precise signaling mechanisms and physiological roles require further investigation.

Conclusions:

SUCNR1 is a crucial regulator of physiological processes with significant therapeutic potential.
Further research into SUCNR1 modulators is essential for drug development.
Understanding SUCNR1 pathways is key to addressing related diseases.