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Canine Cutaneous and Subcutaneous Soft Tissue Sarcoma: An Evidence-Based Review of Case Management
Ann E Hohenhaus1, Jennifer L Kelsey, Jamie Haddad1
1From the Animal Medical Center, New York, NY (A.E.H.); Stanford University, Stanford, CA (J.L.K.); IDEXX Laboratories, New York, NY (J.H.); Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA (L.B.); VCA Veterinary Referral and Emergency Center, Norwalk, CT (M.P.); the Veterinary Cancer Center, Norwalk, CT (J.F.); and Guilford Veterinary Hospital, Guilford, CT (A.S.).
This review provides evidence-based recommendations for diagnosing, treating, and monitoring canine soft tissue sarcomas (STS). Key findings include the importance of biopsy, wide surgical margins, and considering chemotherapy or radiation therapy.
Area of Science:
- Veterinary Oncology
- Canine Neoplasia
Background:
- Canine soft tissue sarcomas (STS) represent a significant portion of malignant skin neoplasms.
- Current literature on STS management often lacks rigorous study design.
Purpose of the Study:
- To provide evidence-based recommendations for the diagnosis, treatment, and follow-up of canine STS.
- To synthesize expert opinion from various veterinary specialties.
Main Methods:
- Comprehensive literature review on canine STS management.
- Consensus-building among board-certified specialists in internal medicine, surgery, pathology, oncology, and radiation oncology.
Main Results:
- Cytology and biopsy are crucial for presurgical planning in canine STS.
- Wide surgical excision (margins >3 cm) is recommended to reduce tumor recurrence.
- Histologic grading aids in predicting STS biologic behavior.
- Chemotherapy and radiation therapy can be beneficial as adjunct treatments for STS.
Conclusions:
- Further research is needed to establish optimal surgical margins, the role of radiation in incompletely resected tumors, ideal chemotherapy protocols for high-grade STS, and monitoring strategies for recurrence and metastasis.
