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Updated: Mar 26, 2026
A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
Published on: June 27, 2018
Development of a Mock Extracorporeal Membrane Oxygenation Circuit to Assess Recirculation
Ishanth Devinda Jayewardene1, Ashleigh Xie, Arjun Iyer
1From the *Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia; †Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia; and ‡St Vincent's Hospital Heart and Lung Transplant Unit, Sydney, New South Wales, Australia.
Abstract:
A limitation of veno-venous extracorporeal membrane oxygenation (VV-ECMO) is the recirculating of newly oxygenated blood back to the VV-ECMO circuit. We compared cannulation strategies for combating recirculation utilizing a mock circulation loop (MCL) with ultrasonic flow probes and pressure transducers ensuring that the MCL was run at physiological hemodynamic parameters. Mean recirculation percentages were lower (ANOVA, F = 14.25; p = 0.0001) with the Wang-Zwische dual lumen cannula (4.00 ± 1.77, n = 7) than both the femoro-jugular (15.23 ± 7.00, n = 8) and the femoro-femoral cannulation configurations (13.49 ± 1.44, n = 8).
