Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.5K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.5K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

1.1K
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
1.1K
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

886
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
886
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

1.1K
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
1.1K
Esophagus01:24

Esophagus

4.6K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
4.6K
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

1.2K
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Phase III, Randomized, Double-Blind, Active-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Tegoprazan for the Prevention of Peptic Ulcer in Patients on Continuous Long-Term Treatment with Nonsteroidal Anti-Inflammatory Drugs.

Gut and liver·2026
Same author

Real‑world Application of the International Anorectal Physiology Working Group Standardized Protocol and London Classification: A Multi‑country Cross‑sectional Survey of Anorectal Manometry Practice in Asia.

Journal of neurogastroenterology and motility·2026
Same author

Prior Cancer and Survival in Patients With Esophageal Squamous Cell Carcinoma.

JAMA network open·2026
Same author

Correction to: Randomized, Double-Blind, Active-Controlled Phase 3 Study to Evaluate Efficacy and Safety of Zastaprazan Compared to Esomeprazole in Erosive Esophagitis.

The American journal of gastroenterology·2026
Same author

Randomized, Double-Blind, Active-Controlled, Parallel, Phase 3 Clinical Trial for Evaluating the Efficacy and Safety of Zastaprazan in Patients with Gastric Ulcers.

Gut and liver·2026
Same author

Spatiotemporal Remodeling of Enteric Neural Pathways Underlies Colonic Dysmotility Following Spinal Cord Injury in Rats.

Journal of neurogastroenterology and motility·2026
Same journal

Macro-Aspartate Aminotransferase Elevation in a Patient with Chronic Hepatitis B.

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·2026
Same journal

Fatal Clinical Course of Hepatic Portal Venous Gas Associated with Thrombosed Abdominal Aortic Aneurysm.

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·2026
Same journal

Risk Factors for Adverse Circulatory and Respiratory Events in Patients Undergoing Esophageal Endoscopic Submucosal Dissection Under Dexmedetomidine-Based Sedation.

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·2026
Same journal

[Achievements and Future Directions of the National Colorectal Cancer Screening Program in Korea].

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·2026
Same journal

[Advanced Combination Therapy in Inflammatory Bowel Disease].

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·2026
Same journal

[Immunotherapy and Targeted Therapy for Advanced Biliary Tract Cancer].

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

9.0K

[Minimal Change Esophagitis].

Han Seung Ryu1, Suck Chei Choi1

  • 1Department of Internal Medicine, Wonkwang University College of Medicine and Digestive Disease Research Institute, Iksan, Korea.

The Korean Journal of Gastroenterology = Taehan Sohwagi Hakhoe Chi
|January 27, 2016
PubMed
Summary
This summary is machine-generated.

Minimal change esophagitis, often seen in gastroesophageal reflux disease (GERD), lacks clear definition and diagnostic criteria. This review clarifies its histology, interobserver agreement, and clinical significance in GERD patients.

Keywords:
DiagnosisEsophagitisGastroesophageal reflux

More Related Videos

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

15.5K
Robotic Myotomy and Partial Fundoplication for Achalasia
11:19

Robotic Myotomy and Partial Fundoplication for Achalasia

Published on: August 11, 2023

2.1K

Related Experiment Videos

Last Updated: Mar 26, 2026

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
05:57

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection

Published on: February 10, 2017

9.0K
An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function
09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

15.5K
Robotic Myotomy and Partial Fundoplication for Achalasia
11:19

Robotic Myotomy and Partial Fundoplication for Achalasia

Published on: August 11, 2023

2.1K

Area of Science:

  • Gastroenterology
  • Digestive System Disorders
  • Esophageal Diseases

Background:

  • Gastroesophageal reflux disease (GERD) is characterized by troublesome symptoms and complications from gastric content reflux.
  • GERD encompasses erosive reflux disease and non-erosive reflux disease, distinguished by endoscopic mucosal breaks.
  • The Los Angeles classification omits minimal changes due to poor interobserver agreement, yet they are frequently observed in clinical practice.

Purpose of the Study:

  • To define minimal change esophagitis.
  • To review the histology associated with minimal change esophagitis.
  • To assess interobserver agreement and symptom association for minimal change esophagitis in GERD.

Main Methods:

  • Literature review focusing on endoscopic findings in GERD.
  • Analysis of studies defining minimal change esophagitis and its histological features.
  • Evaluation of research on interobserver agreement and clinical significance of minimal changes.

Main Results:

  • Minimal changes are frequently recognized endoscopically in GERD patients.
  • The clinical significance and diagnostic criteria for minimal change esophagitis remain controversial.
  • Histological findings and interobserver agreement require further standardization.

Conclusions:

  • Minimal change esophagitis is a common endoscopic finding in GERD, but its definition and clinical relevance are debated.
  • Further research is needed to establish standardized diagnostic criteria and understand the symptom association of minimal change esophagitis.
  • Clarifying minimal change esophagitis is crucial for accurate GERD diagnosis and management.