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Asthma-III: Symptoms and Complications

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Antiasthma Drugs: Leukotriene Modifiers

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

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Related Experiment Video

Updated: Mar 26, 2026

Acupuncture in a Rat Model of Asthma

Acupuncture in a Rat Model of Asthma

Published on: August 25, 2020

n-3 Fatty acids and asthma.

Aishwarya Kumar¹, Sarabjit S Mastana¹, Martin R Lindley¹

¹1Translational Chemical Biology Research Group,Human Cellular and Molecular Genetics Research Laboratory,School of Sport, Exercise and Health Sciences,Loughborough University,Loughborough LE11 3TU,UK.

Nutrition Research Reviews

|January 27, 2016

Summary

Omega-3 polyunsaturated fatty acids (n-3 PUFA) may help reduce asthma inflammation and symptoms. Supplementation with these marine-based fatty acids, like EPA and DHA, offers a safe, non-pharmacological approach to managing asthma.

Keywords:

AA AHR airway hyper-responsiveness ALA α-linolenic acid Asthma COX cyclo-oxygenase EIB exercise-induced bronchoconstriction FEV1 forced expiratory volume in 1 s FeNO fractional exhaled NO Fish oils Inflammation LA linoleic acid LOX lipoxygenase LT leukotriene LX lipoxin NOS NO synthase Omega-3 fatty acids PD protectin PEF peak expiratory flow Rv resolvin arachidonic acid n-3 Fatty acids

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Last Updated: Mar 26, 2026

Acupuncture in a Rat Model of Asthma

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Published on: August 25, 2020

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Area of Science:

Immunology
Nutritional Science
Respiratory Medicine

Background:

Asthma affects over 300 million people globally, presenting a significant public health challenge.
Omega-3 polyunsaturated fatty acids (n-3 PUFA) show potential anti-inflammatory effects in various conditions, including asthma.

Purpose of the Study:

To explore the potential benefits of n-3 PUFA supplementation as a complementary therapy for asthma.
To investigate the mechanisms by which n-3 PUFA may reduce asthma severity and inflammation.

Main Methods:

Review of observational and intervention studies on n-3 PUFA and inflammatory diseases.
Analysis of proposed mechanisms involving cell membrane composition and lipid mediator generation (e.g., resolvins).

Main Results:

n-3 PUFA supplementation, particularly EPA and DHA, may alter cell membrane composition.
This alteration can lead to the production of less inflammatory eicosanoids and pro-resolving mediators like E-series resolvins.
Reduced inflammation may attenuate asthma symptoms such as dyspnea and promote bronchodilation.

Conclusions:

n-3 PUFA supplementation is a promising non-pharmacological intervention for asthma.
The anti-inflammatory and inflammation-resolving properties of n-3 PUFA, with no reported major side effects, make them an attractive option for asthma management.