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Expression of Exogenous Antigens in the Mycobacterium bovis BCG Vaccine via Non-genetic Surface Decoration with the Avidin-biotin System
Published on: January 31, 2018
Manipulation of BCG vaccine: a double-edged sword
V K Singh1, R Srivastava2, B S Srivastava2
1Section for Immunology, Department of Experimental Medical Science, Lund University, BMC D14, 22184, Lund, Sweden. vipulsingh05@gmail.com.
Recombinant BCG (rBCG) vaccines show promise for tuberculosis (TB) prevention, but careful genetic manipulation is needed to balance efficacy and safety. Further research into rBCG limitations is crucial for developing improved TB vaccines.
Area of Science:
- Immunology
- Vaccinology
- Microbiology
Background:
- Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is the sole licensed tuberculosis (TB) vaccine, yet its efficacy against pulmonary TB is inconsistent in older populations.
- Despite advances in biological sciences, TB and HIV/AIDS remain significant global health challenges.
Purpose of the Study:
- To review the potential of recombinant BCG (rBCG) vaccines expressing Mycobacterium tuberculosis (Mtb) antigens for improved TB prevention.
- To discuss the limitations and potential adverse effects associated with genetic manipulation of BCG for vaccine development.
Main Methods:
- Review of existing literature on rBCG vaccine development and immunological responses.
- Analysis of genetic manipulation strategies for enhancing BCG vaccine immunogenicity and safety.
Main Results:
- rBCG vaccines offer a potential strategy for developing more immunogenic TB vaccines with improved safety profiles.
- Genetic manipulation of BCG can lead to both beneficial and detrimental outcomes, necessitating careful consideration.
Conclusions:
- rBCG vaccines expressing Mtb antigens represent a promising avenue for novel TB vaccine development.
- Understanding the limitations of rBCG manipulation is key to advancing vaccine design and overcoming challenges in TB control.
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