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Updated: Mar 26, 2026

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Pediatric intestinal obstruction in Malawi: characteristics and outcomes
Mansi Shah1, Jared Gallaher1, Nelson Msiska2
1Department of Surgery, University of North Carolina, 4008 Burnett Womack Building, CB 7228, Chapel Hill, NC, USA.
Background:
Intestinal obstruction (IO) is a common pediatric surgical emergency in sub-Saharan Africa with high morbidity and mortality, but little is known about its etiopathogenesis in Malawi.
Methods:
Retrospective analysis of patients seen from February 2012 to June 2014 at Kamuzu Central Hospital in Lilongwe, Malawi (n = 3,407). Pediatric patients with IO were analyzed (n = 130).
Results:
Overall, 57% of patients were male with a mean age of 3.5 ± 4.1 years. A total of 52% of patients underwent operative intervention. The overall mortality rate was 3%. Leading causes of IO were Hirschprung's 29%, anorectal malformation 18%, and intussusception 4%. Neonates and patients with congenital causes of IO underwent surgery less frequently than infants and/or children and patients with acquired causes, respectively. These groups also demonstrated increased number of days from admission to surgery.
Conclusions:
Increasing pediatric-specific surgical education and/or training and expanding access to resources may improve mortality after IO in poor medical communities within sub-Saharan Africa.
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