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Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
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Aortic aneurysm association with SLE - a case-control study.

A Guy1, S Tiosano1, D Comaneshter2

  • 1Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Lupus
|January 27, 2016
PubMed
Summary
This summary is machine-generated.

Patients with systemic lupus erythematosus (SLE) have a significantly higher risk of developing aortic aneurysms. This finding highlights a critical association requiring increased clinical awareness for early detection and management.

Keywords:
Systemic lupus erythematosusaortic aneurysmatherosclerosisinflammationvascular disease

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Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Medical Databases

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease associated with severe cardiovascular complications.
  • Aortic aneurysms represent a life-threatening condition that may be linked to SLE.

Purpose of the Study:

  • To investigate the association between SLE and the occurrence of aortic aneurysms.
  • To determine if SLE increases the risk of developing aortic aneurysms.

Main Methods:

  • A case-control study comparing patients with SLE to age- and sex-matched controls.
  • Utilized the Clalit Health Services medical database for patient data.
  • Employed Chi-square and t-tests for univariate analysis and logistic regression for multivariate analysis.

Main Results:

  • The study included 5018 patients with SLE and 25,090 controls.
  • Aortic aneurysm prevalence was higher in SLE patients (0.6%) compared to controls (0.1%), p < 0.001.
  • Multivariate analysis revealed SLE is associated with aortic aneurysms (OR 2.06, 95% CI 1.21-3.51).

Conclusions:

  • Patients with SLE exhibit a significantly higher proportion of aortic aneurysms.
  • This association underscores the need for heightened physician awareness when managing SLE patients.
  • Early recognition of aortic aneurysms in SLE patients is crucial for managing this life-threatening risk.