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Updated: Mar 26, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
Parvovirus leading to thrombotic microangiopathy in a healthy adult
Bhanu Prasad1, Jennifer St Onge2
1Department of Nephrology, Regina Qu'Appelle Health Region, Regina, Saskatchewan, Canada University of Saskatchewan, Regina, Saskatchewan, Canada.
Abstract:
A healthy 47-year-old man initially presented with symptoms of body rash, myalgias, dark urine, nausea and vomiting. Acute kidney injury, and positive urine analysis for blood and protein warranted a kidney biopsy, which revealed micro thrombi in kidney vasculature, suggestive of thrombotic microangiopathy. Serology revealed positive parvovirus B19 IgM antibodies and biopsy tests revealed a viral genome on PCR. Despite plasma exchanges and treatment with rituximab, renal function continued to deteriorate to end-stage renal disease.
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