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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Emerging role of Hippo pathway in gastric and other gastrointestinal cancers

Wei Kang1, Alfred S L Cheng1, Jun Yu1

  • 1Wei Kang, Ka Fai To, Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

World Journal of Gastroenterology
|January 27, 2016
PubMed

Insights

The Hippo signaling pathway regulates gastrointestinal tissue. Its deregulation, particularly involving YAP1/TAZ, drives tumorigenesis, offering potential therapeutic targets for gastrointestinal cancers.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Gastroenterology

Background:

  • The Hippo signaling pathway is crucial for maintaining gastrointestinal tissue homeostasis.
  • Deregulation of this pathway, especially the YAP1/TAZ effectors, is linked to tumorigenesis.
  • YAP1/TAZ function as transcriptional co-activators interacting with TEAD factors.

Purpose of the Study:

  • To review recent advancements in understanding Hippo pathway deregulation in gastrointestinal tract tumorigenesis.
  • To discuss the molecular mechanisms by which Hippo pathway dysregulation contributes to cancer development.
  • To highlight the prognostic significance of YAP1 in gastrointestinal cancers.

Main Methods:

  • Literature review of recent research on the Hippo pathway in gastrointestinal cancers.
  • Analysis of molecular mechanisms involving YAP1/TAZ and their interaction with TEAD transcription factors.
  • Examination of cross-talk between Hippo pathway and other signaling cascades (GPCR, Wnt/β-catenin, Notch, TGF-β).

Main Results:

  • Hippo pathway deregulation, mediated by YAP1/TAZ, promotes oncogenic activities in gastrointestinal tissues.
  • YAP1 expression is significantly correlated with poor prognosis in gastric and other gastrointestinal cancers.
  • The pathway is influenced by factors like cell density, cell junctions, and microRNAs.

Conclusions:

  • Understanding Hippo pathway regulation in tumorigenesis provides critical insights for therapeutic strategies.
  • Targeting YAP1/TAZ or related pathways may offer novel interventions for gastrointestinal cancers.
  • Further research into Hippo pathway cross-talk and regulatory mechanisms is warranted.
Keywords:
Hippo signaling pathwayMicroRNAOncogenic roleTumor suppressorYes-associated protein 1

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