Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Extraction: Advanced Methods

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reprogrammable Bistable Metasurface for Arbitrary Electromagnetic Wave Manipulation.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Regenerable PVA Hydrogel-Functionalized Optical Fiber Sensor for Ultra-Trace Detection of Berberine Hydrochloride.

Langmuir : the ACS journal of surfaces and colloids·2026

Same author

Spatiotemporal Mapping of Field-Driven Electron Spillover across ZnO Facets.

Angewandte Chemie (International ed. in English)·2026

Same author

Automatic classification of circulating blood cell clusters based on multi-channel flow cytometry imaging.

Engineering applications of artificial intelligence·2026

Same author

First-trimester plasma targeted metabolomics for eicosanoids reveals predictive potential and preventive targets for severe preeclampsia: a nested case-control study.

BMC pregnancy and childbirth·2026

Same author

Achieving Highly Sensitive In Situ Detection of Trace Starch with a Hydrogel-Functionalized MZI Optical Fiber Biosensor.

Langmuir : the ACS journal of surfaces and colloids·2026

Search research articles

Related Experiment Video

Updated: Mar 26, 2026

Graphene Enclosure of Chemically Fixed Mammalian Cells for Liquid-Phase Electron Microscopy

Graphene Enclosure of Chemically Fixed Mammalian Cells for Liquid-Phase Electron Microscopy

Published on: September 21, 2020

Cholesterol Extraction from Cell Membrane by Graphene Nanosheets: A Computational Study.

Liuyang Zhang¹, Bingqian Xu¹, Xianqiao Wang¹

¹College of Engineering and NanoSEC, University of Georgia , Athens, Georgia 30602, United States.

The Journal of Physical Chemistry. B

|January 27, 2016

Summary

Graphene can extract cholesterol from cell membranes, offering a novel biomedical approach. This study explores graphene

More Related Videos

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Published on: June 13, 2021

Ganglioside Extraction, Purification and Profiling

Ganglioside Extraction, Purification and Profiling

Published on: March 12, 2021

Related Experiment Videos

Last Updated: Mar 26, 2026

Graphene Enclosure of Chemically Fixed Mammalian Cells for Liquid-Phase Electron Microscopy

Graphene Enclosure of Chemically Fixed Mammalian Cells for Liquid-Phase Electron Microscopy

Published on: September 21, 2020

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Published on: June 13, 2021

Ganglioside Extraction, Purification and Profiling

Ganglioside Extraction, Purification and Profiling

Published on: March 12, 2021

Area of Science:

Biomedical Engineering
Materials Science
Computational Chemistry

Background:

High cholesterol levels pose significant health risks, driving research into effective reduction strategies.
Current methods primarily involve pharmaceuticals, with limited exploration of nanomaterials for cholesterol removal.
Graphene's unique properties, including its porous structure and adhesion, suggest potential for cholesterol extraction.

Purpose of the Study:

To investigate the feasibility of using graphene nanosheets for extracting cholesterol from cell membranes.
To explore the interaction dynamics between graphene and cholesterol molecules during the extraction process.
To provide a computational basis for developing graphene-based biomedical applications for cholesterol management.

Main Methods:

Utilized dissipative dynamic simulations with a coarse-grained graphene nanosheets (CGGN) model.
Simulated the self-assembly of graphene with cholesterol molecules in an aqueous environment.
Analyzed the dynamic process of cholesterol extraction from a model cell membrane by graphene.

Main Results:

Demonstrated successful self-assembly between graphene and cholesterol molecules, facilitating interaction.
Confirmed graphene's capability to effectively remove cholesterol molecules from a bilayer cell membrane model.
Highlighted the critical role of graphene-cholesterol interactions in determining the efficiency of cholesterol extraction.

Conclusions:

Graphene shows significant promise as a nanomaterial for extracting cholesterol from biological membranes.
The study provides foundational insights into the mechanisms of graphene-mediated cholesterol removal.
Findings suggest a new direction for exploiting graphene's properties in biomedical applications for health.