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Related Experiment Videos

Obesity.

W H Dietz1

  • 1New England Medical Center, Boston, Massachusetts 02111.

Journal of the American College of Nutrition
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Clinical Research Centers have significantly advanced obesity research over 20 years. Studies show obesity impacts fat cell size and number, with complications like Type II diabetes and hypertension, and altered metabolic rates.

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Clinical Research

Background:

  • Obesity research has been a major focus in US Clinical Research Centers (CRCs) for two decades.
  • Obesity is defined by excess body fat, with early onset linked to increased fat cell number.

Purpose of the Study:

  • To review the progress in understanding obesity driven by CRC-based research.
  • To highlight key findings regarding obesity's physiological impacts and complications.

Main Methods:

  • Review of CRC-based research on obesity.
  • Analysis of body fat measurements (triceps skinfold thickness).

Main Results:

  • Weight loss affects fat cell size, not number.
  • Obesity is associated with Type II diabetes, hypertension, increased lipids, and gallstones.

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  • Obese individuals may have higher energy needs, and their metabolic rates increase with overfeeding, especially carbohydrates.

    • Conclusions:

    • CRC research has elucidated the complex nature of obesity, including its cellular, metabolic, and clinical implications.
    • Understanding obesity's impact on fat cells, metabolism, and associated diseases is crucial for management.