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Nutrition and neurodevelopmental outcomes in preterm infants: a systematic review

Stephanie H T Chan1, Mark J Johnson2,3, Alison A Leaf2,3

  • 1Faculty of Medicine, University of Southampton, Southampton, UK.

Acta Paediatrica (Oslo, Norway : 1992)
|January 28, 2016
PubMed

Insights

Increased nutritional intake during the neonatal period may improve neurodevelopmental outcomes for premature infants. Further research is needed to clarify this relationship and establish standardized interventions.

Area of Science:

  • Neonatal Medicine
  • Neuroscience
  • Nutritional Science

Background:

  • Premature infants (<32 weeks gestation or <1501g) face risks of impaired neurodevelopment.
  • Early nutrition is crucial for infant development, but its impact on neurodevelopment in high-risk neonates requires investigation.

Purpose of the Study:

  • To systematically review and meta-analyze the effects of increased nutritional intake on neurodevelopmental outcomes in preterm infants.
  • To assess the impact of macronutrient or multinutrient interventions during the neonatal period.

Main Methods:

  • Systematic review and meta-analysis of existing studies.
  • Inclusion of infants born at <32 weeks gestation or weighing <1501g at birth.
  • Analysis of neurodevelopmental outcomes following nutritional interventions.

Main Results:

  • Preliminary evidence suggests a potential benefit of increased early nutrition in reducing neurodevelopmental impairment.
  • The precise relationship between nutritional intake and neurodevelopmental outcomes remains unclear.

Conclusions:

  • Increased early nutrition may be associated with reduced neurodevelopmental impairment in high-risk infants.
  • Standardized nutritional interventions and agreed-upon neurodevelopmental assessment batteries are recommended for future research.
Abstract

Keywords:
InfantLow birthweightNeurodevelopmentNutritionVery preterm

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