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Mirtazapine withdrawal-induced mania
Jitendra Kumar Verma1, Satyakam Mohapatra2
1Department of Psychiatry, Mahamaya Rajkiya Allopathic Medical College, Uttar Pradesh, India.
Journal of Pharmacology & Pharmacotherapeutics
|January 28, 2016
Summary
Antidepressant withdrawal mania is rare. This case report details a patient experiencing a manic episode after discontinuing mirtazapine, a novel finding.
Area of Science:
- Psychiatry
- Neuroscience
- Pharmacology
Background:
- Antidepressant withdrawal symptoms are varied but mania is uncommon.
- Mirtazapine is a common antidepressant, but its withdrawal-induced mania is poorly documented.
Observation:
- A patient presented with a manic episode.
- The episode occurred after the cessation of mirtazapine treatment.
Findings:
- This case represents a manic episode, not just hypomania, upon mirtazapine withdrawal.
- This is the second reported instance globally and the first detailing a full manic episode.
Implications:
- Clinicians should be aware of the potential for manic episodes during mirtazapine withdrawal.
- Further research is needed to understand the neurobiological mechanisms underlying antidepressant withdrawal-induced mania.
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