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Long-Term Distributed Repetitive Transcranial Magnetic Stimulation for Tinnitus: A Feasibility Study.

Douglas Labar^1,2, Amy S Labar^1,2, Dylan Edwards^1,2

¹Non-invasive Brain Stimulation Laboratory, Burke Medical Research Institute, White Plains, NY, USA.

Neuromodulation : Journal of the International Neuromodulation Society

|January 29, 2016

Summary

This study found that long-term, distributed transcranial magnetic stimulation (TMS) therapy is feasible and well-tolerated for refractory tinnitus. The treatment showed potential clinical benefits, suggesting it as an alternative to shorter schedules.

Keywords:

Auditory cortex stimulation cerebral cortex stimulation neurostimulation tinnitus transcranial magnetic stimulation

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Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain

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Published on: October 22, 2016

Area of Science:

Neuroscience
Otolaryngology
Neuromodulation

Background:

Refractory tinnitus significantly impacts quality of life.
Current treatment schedules for transcranial magnetic stimulation (TMS) are often short-term and aggregated.
Long-term, distributed therapeutic schedules for TMS remain largely unexplored.

Purpose of the Study:

To evaluate the feasibility and tolerability of a seven-month distributed therapeutic repetitive transcranial magnetic stimulation (rTMS) protocol for refractory tinnitus.
To assess the clinical benefit and safety of this long-term rTMS approach.

Main Methods:

Eight subjects with refractory tinnitus received weekly 1 Hz rTMS targeting the temporoparietal junction for five weeks.
Responders entered a monthly rTMS maintenance phase for five additional months.
Outcomes included subject satisfaction, compliance, tinnitus severity, and adverse events.

Main Results:

High subject satisfaction and near 100% compliance were observed.
Significant improvements in tinnitus severity were noted at week 5.
No serious adverse events were reported during the study.

Conclusions:

A distributed, long-term rTMS schedule is feasible, well-tolerated, and potentially clinically beneficial for refractory tinnitus.
This approach warrants further investigation as an alternative to conventional short-term rTMS protocols.
Further research into varied rTMS treatment schedules is crucial for optimizing therapeutic applications.