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Updated: Mar 26, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
First episode mania following cessation of varenicline (Champix)
Richard Baker1, Nav Gill2, Gordon Parker3
1Associate Conjoint Lecturer, School of Psychiatry, University of New South Wales, Sydney, NSW, and; Chief Registrar, Psychiatry, St Vincent's Public Hospital, Sydney, NSW, Australia.
Objectives:
To describe a case of first episode mania and in which varenicline (Champix) or its withdrawal appears to have been the precipitating factor.
Methods:
The clinical presentation and progress are detailed and the relevant literature in relation to varenicline is provided.
Results:
The case report adds to the literature indicating that varenicline may induce a range of mood states, albeit with reported incidents of mania being rare.
Conclusions:
In reviewing causes of mood states, including mania, seeking information on any exposure to varenicline would appear to be relevant.
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