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Atherosclerotic Vessel Changes in Sarcoidosis
I Tuleta1, S Pingel2, L Biener2
1Department of Internal Medicine II - Cardiology, Pulmonology and Angiology, University of Bonn, 25 Sigmund-Freud-St., D-53105, Bonn, Germany. Izabela.Tuleta@ukb.uni-bonn.de.
Advances in Experimental Medicine and Biology
|January 29, 2016
Summary
Sarcoidosis patients show a higher pulse wave index (PWI), suggesting early atherosclerosis. Standard atherosclerosis markers like ABI and cPWV were similar between sarcoidosis patients and controls.
Area of Science:
- Vascular Medicine
- Rheumatology
- Cardiology
Background:
- Sarcoidosis is a systemic inflammatory disease.
- Atherosclerosis is a chronic inflammatory vascular condition.
- The link between sarcoidosis and atherosclerosis requires further investigation.
Purpose of the Study:
- To investigate the association between sarcoidosis and atherosclerotic vascular changes.
- To assess arterial stiffness and plaque burden in sarcoidosis patients.
Main Methods:
- Prospective cross-sectional study of 71 sarcoidosis patients and 12 matched controls.
- Angiological measurements included ankle brachial index (ABI), central pulse wave velocity (cPWV), pulse wave index (PWI), and duplex sonography.
- Blood tests analyzed sarcoidosis activity markers and cardiovascular risk parameters.
Main Results:
- No significant differences in ABI, cPWV, or plaque burden were observed between groups.
- Pulse wave index (PWI) was significantly higher in sarcoidosis patients compared to controls.
- Elevated lipoprotein(a) and d-dimer were noted in sarcoidosis patients; other cardiovascular markers were similar.
Conclusions:
- Sarcoidosis is associated with an increased pulse wave index (PWI).
- Elevated PWI may indicate an early stage of atherosclerosis in sarcoidosis patients.
- Further research is needed to elucidate the mechanisms linking sarcoidosis and vascular disease progression.
Keywords:
Arterial stiffnessCardiovascular risk factorsSystemic inflammationVascular ultrasoundVasculopathyMore Related Videos
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