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Published on: September 19, 2018
A multi-locus genetic risk score for abdominal aortic aneurysm.
Zi Ye1, Erin Austin2, Daniel J Schaid3
1Division of Cardiovascular Diseases and the Gonda Vascular Center, Mayo Clinic, Rochester, MN, USA.
Genetic risk scores predict abdominal aortic aneurysm (AAA) presence and expansion. A multi-locus genetic risk score (GRS) identified individuals at higher risk for AAA and faster aneurysm growth.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Medical Research
Background:
- Abdominal aortic aneurysm (AAA) is a life-threatening condition.
- Genetic factors play a role in AAA development.
- Predictive tools for AAA are needed.
Purpose of the Study:
- To investigate the association of a multi-locus genetic risk score (GRS) with AAA presence.
- To determine if GRS predicts AAA progression.
Main Methods:
- Case-control study using data from the Mayo Vascular Disease Biorepository.
- Calculated GRS using 4 single nucleotide polymorphisms (SNPs) associated with AAA.
- Analyzed GRS association with AAA presence and aneurysm growth rate.
Main Results:
- GRS was significantly associated with AAA presence (OR 1.06, 95% CI 1.04-1.09, p < 0.001).
- GRS improved AAA presence prediction when added to conventional risk factors (NRI 14%, p < 0.001).
- Higher GRS was linked to faster aneurysm growth (0.50 mm/year increase, p = 0.01) after adjustments.
Conclusions:
- A multi-locus GRS is associated with the presence of abdominal aortic aneurysm.
- GRS is also associated with increased aneurysm expansion rate.
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