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Updated: Mar 26, 2026

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Production of Virus-Like Particles for Vaccination
Christine M Thompson1,2, Marc G Aucoin3, Amine A Kamen2,4
1Department of Chemical Engineering, Ecole Polytechnique de Montreal, 2500, Chemin de Polytechnique, Montreal, QC, Canada.
Abstract:
The ability to make a large variety of virus-like particles (VLPs) has been successfully achieved in the baculovirus expression vector system (BEVS)/insect cell system. The production and scale-up of these particles, which are mostly sought as vaccine candidates, are currently being addressed. Furthermore, these VLPs are being investigated as delivery agents for use as therapeutics. The use of host insect cells allows mass production of VLPs in a proven scalable system.
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