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Related Concept Videos

Hand hygiene01:23

Hand hygiene

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Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
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The sequence of removing or doffing PPE starts with the gloves, as they are the most contaminated. Next is removal of the face shield or goggles, as they would interfere with removing other PPE. Then remove the gown, followed by the mask or respirator. Perform hand hygiene between steps if hands become contaminated and immediately after removing all PPE. Generally, the outside front and sleeves of the isolation gown, the goggles or the mask, the respirator, and the face shield are contaminated.
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
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"EB, or Not EB?" Neonatal Desquamative Impetigo in a Degloving Pattern.

Tuyet A Nguyen1,2, Audrey S Wang1,3, Lawrence F Eichenfield1,3

  • 1Rady Children's Hospital, San Diego, California.

Pediatric Dermatology
|January 30, 2016
PubMed
Summary

A newborn developed severe blistering mimicking epidermolysis bullosa. The condition was diagnosed as bullous impetigo, caused by Staphylococcus aureus, highlighting newborn skin fragility.

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Area of Science:

  • Neonatal dermatology
  • Bacterial infections
  • Pediatric skin conditions

Background:

  • Neonatal skin is delicate and susceptible to various dermatological conditions.
  • Blistering and desquamation in infants can present diagnostic challenges.
  • Epidermolysis bullosa is a group of genetic disorders characterized by fragile skin.

Observation:

  • A 7-day-old infant presented with rapidly spreading, "degloving" pattern blisters on the hands.
  • The clinical presentation mimicked inherited blistering disorders like epidermolysis bullosa.
  • Bacterial culture identified an aggressive strain of Staphylococcus aureus.

Findings:

  • The infant was diagnosed with bullous impetigo, a skin infection caused by Staphylococcus aureus.
  • Bullous impetigo results from the localized release of exfoliative toxin A by S. aureus.
  • This condition is more frequently observed in pediatric populations.

Implications:

  • This case underscores the importance of considering bacterial infections in neonatal blistering.
  • Accurate diagnosis is crucial for appropriate treatment and management of neonatal skin conditions.
  • Understanding the differential diagnoses for infant blistering is vital for pediatricians and dermatologists.