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Acquired resistance to immunotherapy and future challenges
Nicholas P Restifo1, Mark J Smyth2, Alexandra Snyder3
1Center for Cancer Research, National Cancer Institute and Center for Regenerative Medicine, National Institutes of Health, Bldg 10/CRC, Room 3-5762, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
Acquired resistance to cancer immunotherapy is a significant challenge. Experts discuss evidence for its existence and future therapeutic hurdles.
Area of Science:
- Oncology
- Immunology
- Cancer Therapeutics
Background:
- Immunotherapy has shown significant clinical success in cancer treatment.
- A major limitation is the development of acquired resistance and disease progression during or after therapy.
Purpose of the Study:
- To explore the current evidence for acquired resistance to immunotherapy in patients.
- To identify future challenges in overcoming immunotherapy resistance.
Main Methods:
- Expert opinions sought from three scientists.
- Review of current evidence on immunotherapy resistance.
Main Results:
- Discussion on the existence of acquired resistance to immunotherapy.
- Identification of key challenges in future cancer immunotherapy.
Conclusions:
- Acquired resistance to immunotherapy is a recognized clinical issue.
- Addressing resistance is crucial for advancing cancer therapeutics.
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