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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
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Secukinumab.

Dennis J Cada1, Danial E Baker2, Shannon G Panther3

  • 1Founder and Contributing Editor, The Formulary.

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Summary

The Formulary Monograph Service provides monthly drug monographs and utilization evaluations for Pharmacy & Therapeutics Committees. It offers insights into new and investigational drugs, aiding clinical decision-making.

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Area of Science:

  • Pharmacology and Therapeutics
  • Drug Information Services

Background:

  • The Formulary Monograph Service delivers essential drug information to healthcare professionals.
  • It supports Pharmacy & Therapeutics Committees with timely data on new and emerging therapies.

Purpose of the Study:

  • To provide detailed monographs on newly released and late-phase drugs.
  • To offer drug utilization evaluations (DUE/MUE) for clinical practice.
  • To support pharmacy and nursing in-service education with concise summaries.

Main Methods:

  • Publication of 5-6 detailed monographs per month.
  • Inclusion of 1-page summary monographs for specific agents.
  • Provision of a comprehensive drug utilization evaluation/medication use evaluation (DUE/MUE) monthly.

Main Results:

  • Monographs cover newly released drugs and those in late phase 3 trials.
  • Specific September 2015 topics included cangrelor, lumacaftor/ivacaftor, brexpiprazole, talimogene laherparepvec, and lesinurad.
  • A safety medication use evaluation focused on cangrelor.

Conclusions:

  • The service provides critical, up-to-date drug information for formulary management.
  • Customizable monographs and online access enhance utility for healthcare facilities.
  • Monthly drug class reviews are now integrated into the service.