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Published on: April 12, 2024
Mixed lineage kinase domain-like protein is a prognostic biomarker for cervical squamous cell cancer
Jiaying Ruan1, Ling Mei1, Qian Zhu1
1Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University Renmin South Road, Chengdu 610041, China.
Background:
The mixed lineage kinase domain-like protein (MLKL) has recently been identified as a key RIP3 (receptor interacting protein 3) downstream component of tumor necrosis factor (TNF)-induced necroptosis.
Objective:
To evaluate the expression and clinical significance of MLKL in cervical squamous cell carcinoma.
Methods:
The expression of MLKL in 54 cervical squamous carcinoma samples was detected by immuneohistochemical method. Chi-square, correlation analysis and kaplan-Meier method were used to analyze the data.
Results:
The MLKL expression in cervical squamous cell carcinoma was higher than that in normal cervical tissues (P = 0.004). The MLKL expression was negatively correlated with histological grade, lymphatic metastasis (P<0.05). Survival analysis showed the low expression of MLKL indicated poor prognosis.
Conclusion:
MLKL was a prognostic biomarker for cervical squamous cell carcinoma.
