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Related Concept Videos

Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Role of Myosin in Cell Migration01:18

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Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
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Cytoskeletal Coordination in Cell Migration01:32

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
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Magnetically actuated microstructured surfaces can actively modify cell migration behaviour.

F Khademolhosseini1, C-C Liu2,3, C J Lim2,3

  • 1The University of British Columbia, Vancouver, Canada. khadem@mail.ubc.ca.

Biomedical Microdevices
|January 31, 2016
PubMed
Summary
This summary is machine-generated.

Magnetically actuated polymer micropillar surfaces significantly reduce cell migration rates by over 5-fold. This technology offers novel in-vivo tissue engineering possibilities by remotely controlling cell movement with magnetic fields.

Keywords:
Cell migrationMagnetic micropillarMechanical stimulationPolymer actuator

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Nanotechnology

Background:

  • Cell migration is crucial for tissue development and regeneration.
  • Controlling cell migration is essential for advanced tissue engineering and regenerative medicine.
  • Current methods for controlling cell migration in vivo are limited.

Purpose of the Study:

  • To investigate the efficacy of magnetically actuated polymer micropillar surfaces in modulating cell migration.
  • To determine the impact of micropillar actuation on cell migration rates.
  • To explore the potential of this technology for in-vivo applications.

Main Methods:

  • Fabrication of polymer micropillar surfaces with magnetic properties.
  • Actuation of micropillar surfaces using external magnetic fields at a frequency of 1 Hz.
  • Quantification of cell migration rates on actuated and non-actuated surfaces.
  • Analysis of factors influencing micropillar effectiveness, including density, pattern, and actuation direction.

Main Results:

  • Actuated micropillar surfaces at 1 Hz decreased cell migration rates by over 5-fold compared to controls.
  • Non-actuated micropillar surfaces showed no significant alteration in cell migration rates.
  • Micropillar effectiveness was dependent on density, placement patterns, and actuation direction relative to cell migration.

Conclusions:

  • Magnetically actuated polymer micropillars offer a novel method to significantly impede cell migration.
  • Remote actuation via small magnetic fields enables potential integration with implants.
  • This technology presents new avenues for in-vivo tissue engineering and regenerative medicine applications.