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MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma

Mírian Romitti1, Simone Magagnin Wajner1, Lucieli Ceolin1

  • 1Thyroid SectionEndocrine Division, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2350, CEP 90035-003 Porto Alegre, RS, BrazilExperimental Research CenterHospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilDepartment of Cell and Developmental BiologyInstitute of Biomedical Sciences, Universidade de São Paulo, São Paulo, SP, Brazil.

Endocrine-Related Cancer
|January 31, 2016
PubMed
Summary

Type 3 deiodinase (DIO3) upregulation in papillary thyroid carcinoma (PTC) is linked to MAPK and sonic hedgehog pathways. Inhibiting DIO3 reduces PTC cell proliferation, suggesting its role in tumor growth.

Keywords:
MAPK genetic alterationsSonic Hedgehog pathwaytype 3 deiodinase, papillary thyroid carcinoma

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