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Updated: Mar 26, 2026

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Published on: May 5, 2014
Relationship of long noncoding RNA and viruses
Yao-zhong Ding1, Zhong-wang Zhang1, Ya-li Liu1
1State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu 225009, China.
Long noncoding RNAs (lncRNAs) show potential as cancer prognosis markers and antiviral drug targets. Research indicates their role in viral replication and immune evasion, suggesting therapeutic applications.
Area of Science:
- Molecular Biology
- Genomics
- Virology
Background:
- Long noncoding RNAs (lncRNAs) are diverse RNA transcripts with emerging roles in cellular processes.
- Over 200 lncRNAs have been studied in vitro, revealing potential clinical significance.
Purpose of the Study:
- To explore the multifaceted roles of lncRNAs in cancer prognosis and viral infections.
- To identify lncRNAs as potential therapeutic targets for antiviral drug development.
Main Methods:
- In vitro studies analyzing the functions and mechanisms of over 200 lncRNAs.
- Review of existing literature on lncRNA involvement in viral replication and immune response.
Main Results:
- lncRNAs may serve as molecular markers for cancer patient prognosis.
- Certain lncRNAs facilitate virus replication and suppress host antiviral immunity.
- Examples include lncRNA in persistent Theiler's virus infection and miR-27a/b in MCMV replication.
Conclusions:
- lncRNAs represent a promising class of biomarkers for cancer prognostication.
- lncRNAs are implicated in viral pathogenesis, highlighting their potential as targets for novel antiviral therapies.
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