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The IPD-IMGT/HLA Database - New developments in reporting HLA variation.

James Robinson1, Anup R Soormally2, James D Hayhurst2

  • 1Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK; UCL Cancer Institute, University College London, Royal Free Campus, Pond Street, Hampstead, London NW3 2QG, UK.

Human Immunology
|January 31, 2016
PubMed
Summary
This summary is machine-generated.

The IPD-IMGT/HLA database provides a centralized, searchable repository of highly curated human Major Histocompatibility Complex (MHC) allele sequences. This resource supports the study of immune system gene polymorphism, with some genes having over 4000 variants.

Keywords:
AlleleDatabaseHLAImmunogeneticsMHCPolymorphismSequenceVariation

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Area of Science:

  • Immunogenetics
  • Bioinformatics
  • Molecular Biology

Background:

  • The Immuno Polymorphism Database (IPD) centralizes the study of immune system gene polymorphism.
  • The IPD-IMGT/HLA Database is a key component, focusing on the human Major Histocompatibility Complex (MHC).
  • It builds upon decades of work by the WHO Nomenclature Committee for Factors of the HLA system.

Purpose of the Study:

  • To provide a publicly accessible, online, and searchable repository of highly curated HLA allele sequences.
  • To support research into the hyper-polymorphic nature of immune system genes.
  • To facilitate the study of genetic variations within the human MHC.

Main Methods:

  • Curating and maintaining locus-specific databases for HLA gene sequences.
  • Utilizing the expertise of nomenclature committees and the HLA Informatics Group.
  • Collaborating with the European Bioinformatics Institute for data management and accessibility.

Main Results:

  • The IPD-IMGT/HLA Database offers a comprehensive collection of HLA allele sequences.
  • It currently documents over 4000 allelic variants for some hyper-polymorphic genes.
  • Public access to this curated data is available via a dedicated website.

Conclusions:

  • The IPD-IMGT/HLA Database is an essential resource for immunogenetics research.
  • It significantly enhances the study of human immune system gene diversity.
  • Continued curation and public access are crucial for advancing the field.