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Updated: Mar 26, 2026

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
Published on: June 9, 2017
Note: Magnetic targeting for enhancement of the activation efficiency of G protein-coupled receptor with a two-pair
Quanliang Cao1, Xiaotao Han1, Lei Chun2
1Wuhan National High Magnetic Field Center, Huazhong University of Science and Technology, Wuhan 430074, China.
Abstract:
Insufficient contact of drug with target cells is a primary reason for limited efficiency of G protein-coupled receptor activation. To overcome this limitation, a simple approach based on magnetic targeting for enhancing drug delivery towards the cell surfaces using magnetic nanoparticles and a two-pair coil system consisting of Helmholtz and Maxwell coils was reported. As a proof of the concept, comparative experiments on G protein-coupled receptor activation process were carried out and results show that the efficiency of G protein-coupled receptor activation can be increased about 6 times in the experiments with the aid of the proposed magnetic targeting system.
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