Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)01:20

Spin–Spin Coupling: Two-Bond Coupling (Geminal Coupling)

1.9K
Two NMR-active nuclei bonded to a central atom can be involved in geminal or two-bond coupling. Geminal coupling is commonly seen between diastereotopic protons in chiral molecules and unsymmetrical alkenes, among others.
The central atom need not be NMR-active because its electrons are affected by the electron polarization of the spin-active atoms. However, spin information is transmitted less effectively than in one-bond coupling, and 2J values are usually weaker than 1J values. The energy of...
1.9K
Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)01:22

Spin–Spin Coupling: Three-Bond Coupling (Vicinal Coupling)

1.7K
Vicinal or three-bond coupling is commonly observed between protons attached to adjacent carbons. Here, nuclear spin information is primarily transferred via electron spin interactions between adjacent C‑H bond orbitals. This generally favors the antiparallel arrangement of spins, so 3J values are usually positive.
The extent of coupling depends on the C‑C bond length, the two H‑C‑C angles, any electron-withdrawing substituents, and the dihedral angle between the involved orbitals. The...
1.7K
Spin–Spin Coupling: One-Bond Coupling01:17

Spin–Spin Coupling: One-Bond Coupling

1.6K
Coupling interactions are strongest between NMR-active nuclei bonded to each other, where spin information can be transmitted directly through the pair of bonding electrons. While nuclei polarize their electrons to the opposite spins, the bonding electron pair has opposite spins. Configurations with antiparallel nuclear spins are expected to be lower in energy. When coupling makes antiparallel states more favorable, J is considered to have a positive value. The one-bond coupling constant, 1J,...
1.6K
Spin–Spin Coupling Constant: Overview01:08

Spin–Spin Coupling Constant: Overview

1.6K
In bromoethane, the three methyl protons are coupled to the two methylene protons that are three bonds away. In accordance with the n+1 rule, the signal from the methyl protons is split into three peaks with 1:2:1 relative intensities. The methylene protons appear as a quartet, with the relative intensities of 1:3:3:1.
Qualitatively, any spin plus-half nucleus polarizes the spins of its electrons to the minus-half state. Consequently, the paired electron in the hydrogen–carbon bond must...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coupling a gas gun with an X-pinch x-ray source to perform x-ray diffraction under shock loading.

The Review of scientific instruments·2025
Same author

3D culturing as a promising strategy to enhance the angiogenic potential of adipose stem cell-derived secretome: insights into the role of miR-145-5p/ANGPT2 axis.

Stem cell research & therapy·2025
Same author

Comparing cardiorespiratory fitness and physical activity levels between third- and fifth-year medical students in a South African university.

South African journal of sports medicine·2024
Same author

Impact of drug consumption rooms on non-fatal overdoses, abscesses and emergency department visits in people who inject drugs in France: results from the COSINUS cohort.

International journal of epidemiology·2022
Same author

Improving sample preheating capabilities for dynamic loading on high-pulsed power drivers.

The Review of scientific instruments·2021
Same author

Statistical analysis of the effluent quality of 231 on-site sanitation facilities in France monitored during a 6-year period.

Water science and technology : a journal of the International Association on Water Pollution Research·2019
Same journal

A compact low-power magnetic particle imaging scanner based on a permanent-magnet field-free-line generator with high gradient.

The Review of scientific instruments·2026
Same journal

Achieving ultrahigh resolution with high efficiency: Optical design of the two-dimensional Resonant Inelastic X-ray Scattering (2D-RIXS) spectrometer at NanoTerasu beamline 02U.

The Review of scientific instruments·2026
Same journal

Automated laboratory x-ray diffractometer and fluorescence spectrometer for high-throughput materials characterization.

The Review of scientific instruments·2026
Same journal

Nonlinear Bayesian Doppler tomography for simultaneous reconstruction of flow and temperature.

The Review of scientific instruments·2026
Same journal

A Reflectance-based multimodal wearable photoplethysmography (PPG) sensor.

The Review of scientific instruments·2026
Same journal

Temporal analysis of products-Raman (TAP-Raman): An integrated setup for operando spectroscopy and transient kinetic analysis.

The Review of scientific instruments·2026
See all related articles

Related Experiment Video

Updated: Mar 26, 2026

Hyperpolarized Xenon for NMR and MRI Applications
16:20

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

20.3K

Note: Spin-exchange optical pumping in a van.

C Chauvin1, L Liagre1, C Boutin2

  • 1SB2SM, CEA, CNRS, Université Paris-Saclay, CEA Saclay, 91191 Gif sur Yvette, France.

The Review of Scientific Instruments
|February 1, 2016
PubMed
Summary
This summary is machine-generated.

A new mobile setup produces laser-polarized noble gases, overcoming nuclear magnetic resonance sensitivity limits. This portable system brings hyperpolarized gas production close to hospitals and labs, enhancing research and diagnostics.

More Related Videos

Gradient Echo Quantum Memory in Warm Atomic Vapor
10:00

Gradient Echo Quantum Memory in Warm Atomic Vapor

Published on: November 11, 2013

13.3K
Silicon Metal-oxide-semiconductor Quantum Dots for Single-electron Pumping
14:58

Silicon Metal-oxide-semiconductor Quantum Dots for Single-electron Pumping

Published on: June 3, 2015

15.5K

Related Experiment Videos

Last Updated: Mar 26, 2026

Hyperpolarized Xenon for NMR and MRI Applications
16:20

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

20.3K
Gradient Echo Quantum Memory in Warm Atomic Vapor
10:00

Gradient Echo Quantum Memory in Warm Atomic Vapor

Published on: November 11, 2013

13.3K
Silicon Metal-oxide-semiconductor Quantum Dots for Single-electron Pumping
14:58

Silicon Metal-oxide-semiconductor Quantum Dots for Single-electron Pumping

Published on: June 3, 2015

15.5K

Area of Science:

  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Quantum Optics
  • Medical Imaging

Background:

  • Nuclear magnetic resonance (NMR) faces sensitivity limitations due to low equilibrium polarization.
  • Hyperpolarization techniques, transferring polarization from ordered systems, offer a solution but require proximity.
  • Existing methods often necessitate specialized facilities, limiting widespread application.

Purpose of the Study:

  • To develop a mobile and standalone spin-exchange optical pumping (SEOP) setup for producing laser-polarized noble gases.
  • To enable on-site production of hyperpolarized gases near clinical or research settings.
  • To address the logistical challenges associated with the proximity requirement for hyperpolarized agent use.

Main Methods:

  • Utilized spin-exchange optical pumping (SEOP) with laser polarization.
  • Designed a mobile, standalone apparatus requiring only compressed air and mains power.
  • Focused on efficient production of laser-polarized noble gases (e.g., Helium-3, Xenon-129).

Main Results:

  • Demonstrated successful production of laser-polarized noble gases in a standalone, mobile configuration.
  • The setup operates effectively in close proximity to the point of use, such as hospitals or research labs.
  • Minimal infrastructure requirements (compressed air, mains power) simplify deployment.

Conclusions:

  • The mobile SEOP setup overcomes the proximity constraint for hyperpolarized noble gas production.
  • This innovation facilitates broader access to hyperpolarized agents for advanced NMR and medical imaging applications.
  • The standalone nature enhances the practicality and accessibility of cutting-edge NMR research and diagnostics.