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Published on: November 11, 2022
A new cembrane-type diterpenoid from Bornean liverwort Chandonanthus hirtellus
Shean-Yeaw Ng1, Takashi Kamada1, Monica Suleiman2
1a Laboratory of Natural Products Chemistry , Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah , Kota Kinabalu 88400 , Malaysia.
Abstract:
A new compound, chandonanol (1), along with four known compounds, chandonanthone (2), iso-chandonanthone (3), anastreptene (4), and (6R,7S)-sesquiphellandrene (5), was isolated from the MeOH extract of Bornean liverwort Chandonanthus hirtellus. The structure of the new metabolite was established by analyses of the spectroscopic data (1D NMR, 2D NMR, HRESIMS, and IR). These compounds were tested for their activity against antibiotic-resistant clinical strains. Chandonanol (1) exhibited potent bactericidal activity against Staphylococcus aureus and Escherichia coli.
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