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Residential mobility and the risk of childhood leukemia

Laura Järvelä1, Jani Raitanen1,2, Sini Erme3

  • 1School of Health Sciences, University of Tampere, 33014, Tampere, Finland.

Cancer Causes & Control : CCC
|February 3, 2016
PubMed
Abstract

Insights

This study found no link between childhood leukemia risk and residential mobility, a measure of population mixing. Moving homes or to larger areas did not increase the risk of childhood leukemia.

Area of Science:

  • Epidemiology
  • Pediatric Oncology
  • Infectious Disease Epidemiology

Background:

  • Childhood leukemia may arise from an infective cause, with population mixing potentially increasing disease risk.
  • Residential mobility serves as an individual-level indicator of population mixing.

Purpose of the Study:

  • To investigate the association between residential mobility and childhood leukemia risk in children under 15.
  • To determine if increased population mixing, indicated by residential moves, correlates with altered leukemia incidence.

Main Methods:

  • A population-based case-control study utilized Finnish registry data from 1990-2011.
  • 1,093 childhood leukemia cases were compared to 3,279 matched controls.
  • Residential mobility history, including migration patterns and destination municipality characteristics, was analyzed using conditional logistic regression.

Main Results:

  • No consistent increase or decrease in childhood leukemia risk was observed across various migration patterns.
  • Overall residential mobility showed odds ratios slightly below unity, indicating no elevated risk.
  • Moving to larger municipalities or those with high migration intensity was not associated with increased leukemia risk.

Conclusions:

  • Higher residential mobility is not associated with an increased risk of childhood leukemia.
  • Moving to municipalities with more inhabitants does not elevate the risk for childhood leukemia.
  • The findings do not support the hypothesis that population mixing, via residential mobility, drives childhood leukemia incidence.
Keywords:
Case–control studiesHuman migrationInfectionLeukemiaPopulation dynamics

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