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Updated: Mar 26, 2026
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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
Published on: January 30, 2014
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Microglial dependent protective effects of neuroactive steroids
Oscar Hidalgo Lanussa, Marco Ávila-Rodriguez, Luis Miguel García-Segura
1"GALLY" International Biomedical Research Consulting LLC, San Antonio, TX 78229, USA. aliev03@gmail.com.
CNS & Neurological Disorders Drug Targets
|February 3, 2016
Summary
Microglia play a key role in brain health and disease. This review discusses how neurosteroids can regulate microglial activation to protect against neuroinflammation and neurodegeneration.
Area of Science:
- Neuroscience
- Immunology
- Pharmacology
Background:
- Microglial cells are crucial for central nervous system (CNS) homeostasis.
- Reactive microglia contribute to neuroinflammation and neurodegeneration via cytokine secretion.
- Chronic microglial activation is implicated in neuroinflammatory brain diseases.
Purpose of the Study:
- To review the role of microglial-mediated damage in the CNS.
- To discuss the therapeutic potential of neurosteroids in modulating microgliosis.
- To highlight neurosteroid effects in reducing brain inflammation.
Main Methods:
- Literature review focusing on microglial cells, neuroinflammation, and neurosteroids.
- Analysis of studies investigating microglial responses to CNS injury.
- Examination of research on estrogenic compounds and their anti-inflammatory effects.
Main Results:
- Microglial activation can be neuroprotective or neurodegenerative depending on the stimulus.
- Estrogenic compounds show promise in regulating microgliosis and inflammation.
- Neurosteroids may offer a strategy to mitigate adverse inflammatory impacts in the brain.
Conclusions:
- Controlled microglial activation is a potential neuroprotective strategy.
- Neurosteroids represent a promising therapeutic avenue for neuroinflammatory conditions.
- Further research into neurosteroids could lead to novel treatments for neurodegenerative diseases.
