Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Security by design in artificial intelligence-enabled energy management systems: a sociotechnical framework.

Frontiers in artificial intelligence·2026

Same author

Long-term ocular symptoms following COVID-19 linked to immune dysregulation, dysautonomia and peripheral neuropathy.

Nature communications·2026

Same author

Risk factors for posterior capsule opacification following phacovitrectomy: a six-year retrospective analysis.

International ophthalmology·2026

Same author

Delusional Infestation, Psychiatric Comorbidity, and Dementia: A Review of 146 Swedish Patients.

Acta dermato-venereologica·2025

Same author

Association Between Alcohol Consumption and Psoriasis: Exploratory Analysis of Crowdsourced Web Search Data in Sweden.

JMIR formative research·2025

Same author

Understanding sustainability data through unit manufacturing process representations: a case study on stone production.

Procedia CIRP·2024

Search research articles

Related Experiment Video

Updated: Mar 26, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Serotonergic Markers in Atopic Dermatitis.

Aram Rasul¹, Husameldin El-Nour, Sol-Britt Lonne-Rahm

¹Dermatology and Venereology Unit, Department of Medicine, Solna, Karolinska University Hospital, Karolinska Institutet, SE-171 76 Stockholm, Sweden. aram.rasul@ki.se.

Acta Dermato-Venereologica

|February 3, 2016

Summary

This summary is machine-generated.

Serotonin system activity in the skin is linked to atopic dermatitis (AD) severity and symptoms. This study found altered serotonin receptor and transporter expression in AD skin, correlating with disease extent and psychological factors.

More Related Videos

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Related Experiment Videos

Last Updated: Mar 26, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Area of Science:

Dermatology
Neuroscience
Immunology

Background:

Atopic dermatitis (AD) is a chronic inflammatory skin disease often exacerbated by stress and anxiety.
The serotonin system is implicated in mood regulation and may influence inflammatory conditions like AD.

Purpose of the Study:

To investigate the expression of serotonin, its receptors (5-HT1A, 5-HT2), and the serotonin transporter protein (SERT) in the skin of AD patients.
To explore the correlation between these serotonergic markers and clinical parameters of AD, including disease severity, pruritus, anxiety, and depression.

Main Methods:

Immunohistochemistry was used to analyze skin biopsies from 28 AD patients (lesional and non-lesional sites).
Expression levels of serotonin, 5-HT1A receptor (5-HT1AR), 5-HT2 receptor (5-HT2AR), and SERT were quantified.
Correlations were assessed with SCORAD, VAS for pruritus, SSP for anxiety, and MADRS-S for depression.

Main Results:

Higher 5-HT1AR immunoreactivity (ir) was observed in the epidermis and dermal mast cells of lesional AD skin.
Increased 5-HT2AR-ir was found in the epidermis and on blood vessels of lesional skin, while a higher signal was noted in the basement membrane of non-lesional skin.
SERT-ir was elevated in the basal epidermal layer of lesional skin, with significant correlations found between serotonergic markers and clinical/psychological assessments.

Conclusions:

Serotonergic mechanisms are demonstrably involved in the pathophysiology of atopic dermatitis.
Altered expression and distribution of serotonin system components in AD skin suggest a role in disease exacerbation and symptom severity.