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Updated: Mar 26, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

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Somatic DNA mutation analysis in targeted therapy of solid tumours.

Bing Yu1, Sandra A O'Toole1, Ronald J Trent1

  • 11 Department of Medical Genomics, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia ; 2 Sydney Medical School (Central), the University of Sydney, NSW 2006, Australia ; 3 Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.

Translational Pediatrics
|February 3, 2016
PubMed
Summary

Somatic mutation analysis is key to personalized cancer medicine, identifying critical driver mutations for targeted therapies. Advances in DNA technology and bioinformatics will overcome current challenges, making this crucial for all cancer management.

Keywords:
DNA testingSomatic mutationcancer genomeclinical implicationmultigene analysissolid tumourstargeted therapy

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