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Updated: Mar 26, 2026
09:08
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
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Sézary Syndrome
Agnieszka W Kubica1, Mark R Pittelkow2
1Department of Dermatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Surgical Pathology Clinics
|February 4, 2016
Summary
Sézary syndrome (SS), a rare and aggressive cutaneous T-cell lymphoma, presents diagnostic challenges. This review updates knowledge on SS diagnosis, pathology, and prognosis, incorporating molecular findings.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Sézary syndrome (SS) is a rare and aggressive form of cutaneous T-cell lymphoma.
- It is characterized by erythroderma and leukemic involvement, often leading to a poor prognosis.
- Limited data exist due to its rarity and diagnostic difficulties.
Purpose of the Study:
- To summarize and update the diagnosis and pathology of Sézary syndrome.
- To highlight microscopic features and novel molecular findings relevant to SS.
- To discuss the diagnostic challenges, differential diagnosis, and prognosis of SS.
Main Methods:
- Literature review focusing on recent large studies.
- Analysis of diagnostic criteria, including microscopic features.
- Examination of molecular findings and prognostic factors.
Main Results:
- SS diagnosis is challenging, requiring differentiation from other cutaneous T-cell malignancies.
- Microscopic examination and molecular data are crucial for accurate diagnosis.
- Recent studies provide updated insights into SS prognosis.
Conclusions:
- Accurate diagnosis of Sézary syndrome is critical due to its poor prognosis.
- Understanding microscopic features and molecular findings aids in diagnosis and management.
- Further research is needed to improve outcomes for SS patients.
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