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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Cutaneous CD30-Positive Lymphoproliferative Disorders.

Werner Kempf1

  • 1Kempf und Pfaltz, Histologische Diagnostik, Seminarstrasse 1, Zürich CH-8042, Switzerland; Department of Dermatology, University Hospital, Zürich CH-8091, Switzerland.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary
This summary is machine-generated.

Cutaneous CD30+ lymphoproliferative disorders, including lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma, are reviewed. This summary covers their variants, diagnoses, and the significance of CD30.

Keywords:
Anaplastic large-cell lymphomaBorderlineCD30Clinico-pathological correlationCutaneousLymphomaLymphomatoid papulosisSystemic

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Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Cutaneous CD30+ lymphoproliferative disorders are the second most frequent cutaneous T-cell lymphomas.
  • This group includes lymphomatoid papulosis (LyP), primary cutaneous anaplastic large-cell lymphoma (pcALCL), and borderline lesions.
  • These disorders share CD30 expression but vary in clinical presentation, disease course, and histology.

Purpose of the Study:

  • To review the clinical, histopathologic, and phenotypic variants of cutaneous CD30+ lymphoproliferative disorders.
  • To discuss differential diagnoses, encompassing both benign and malignant conditions.
  • To elucidate the role of CD30 as a diagnostic, prognostic, and therapeutic marker.

Main Methods:

  • Literature review of clinical, histopathologic, and phenotypic data.
  • Analysis of recently identified variants, such as CD8+ epidermotropic LyP type D, angioinvasive LyP type E, and ALK-positive pcALCL.
  • Synthesis of information regarding diagnostic, prognostic, and therapeutic implications of CD30.

Main Results:

  • Cutaneous CD30+ lymphoproliferative disorders form a spectrum with distinct clinical and histological features.
  • Recent advancements have identified new variants, expanding the classification of these lymphomas.
  • CD30 is a crucial marker for diagnosis, prognosis, and guiding therapy in these conditions.

Conclusions:

  • Understanding the spectrum and variants of cutaneous CD30+ lymphoproliferative disorders is essential for accurate diagnosis and management.
  • CD30 plays a pivotal role in the diagnostic, prognostic, and therapeutic strategies for these lymphomas.
  • Continued research into variants and CD30's role will refine treatment approaches for cutaneous T-cell lymphomas.