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Updated: Mar 10, 2026
Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
Published on: June 10, 2025
The Value of Normal Skin Biopsy for Routine Histopathological Diagnosis of Clinically Invisible Dermatoses: A Review
Maged Daruish1,2, Mohamed Maged3,4, Gerardo Cazzato5
1Cellular Pathology Department, Dorset County Hospital NHS Foundation Trust, Dorchester, UK.
Abstract:
Sampling normal-appearing skin can be a feasible, minimally invasive tool for diagnosing specific systemic diseases and certain "clinically invisible" dermatoses that may show microscopic findings but lack specific cutaneous lesions. Herein, we review the clinical contexts in which biopsy of normal-appearing skin may be indicated for routine histopathological assessment and diagnosis of primary dermatoses or systemic disorders that may otherwise require sampling of internal organs. We also discuss the most appropriate body sites, techniques, and diagnostic histological findings for each of these clinical scenarios.
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