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CNTFR Genotype and Sprint/power Performance: Case-control Association and Functional Studies.
E Miyamoto-Mikami1, Y Fujita2, H Murakami3
1Department of Sports and Life Science, National Institute of Fitness and Sports in Kanoya, Kanoya, Kagoshima Japan.
A genetic variant (rs41274853) in the CNTFR gene was more common in elite sprint athletes and linked to greater power in non-athletes, suggesting a role in athletic performance.
Area of Science:
- Genetics
- Sports Science
- Molecular Biology
Background:
- Elite athletic performance is influenced by genetic factors.
- The ciliary neurotrophic factor receptor gene (CNTFR) plays a role in muscle development and function.
Purpose of the Study:
- To investigate the association of the rs41274853 polymorphism in the CNTFR gene with elite sprint/power athletic status.
- To assess the functional significance of this genetic variant.
Main Methods:
- Genotyping of rs41274853 in 211 Japanese sprint/power athletes and 814 controls.
- Luciferase reporter assay to examine microRNA binding.
- Performance testing (leg extension power, vertical jump) in non-athletes.
Main Results:
- The TT genotype of rs41274853 was significantly more frequent in international sprint/power athletes compared to controls.
- TT genotype carriers showed enhanced leg extension power and vertical jump performance.
- MicroRNA miR-675-5p binding to the CNTFR mRNA was confirmed, independent of the rs41274853 allele.
Conclusions:
- The rs41274853 polymorphism in the CNTFR gene is associated with elite sprint/power athletic status in Japanese individuals.
- While functional mechanisms require further elucidation, CNTFR is a candidate gene for sprint/power performance.
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