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Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: Mar 26, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Hepatitis E in Transplantation.

Olivier Marion¹, Florence Abravanel^2,3,4, Sebastien Lhomme^2,3,4

¹Department of Nephrology and Organ Transplantation, CHU Rangueil, TSA 50032, 31059, Toulouse Cedex 9, France.

Current Infectious Disease Reports

|February 4, 2016

Summary

This summary is machine-generated.

Hepatitis E virus (HEV) can cause chronic hepatitis and cirrhosis in transplant patients. Treatment involves reducing immunosuppression and using ribavirin for effective management of HEV infection.

Keywords:

Chronic hepatitis Extra-hepatic manifestations Hepatitis E virus Ribavirin Transplantation

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Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

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Published on: February 10, 2018

Area of Science:

Hepatology
Virology
Transplant Medicine

Background:

Hepatitis E virus (HEV) is globally prevalent, causing acute and fulminant hepatitis.
HEV is increasingly recognized for causing chronic hepatitis and cirrhosis in immunosuppressed individuals, particularly solid-organ transplant recipients.
Extra-hepatic manifestations, including neurological and renal complications, are associated with HEV in both immunocompetent and immunosuppressed patients.

Purpose of the Study:

To provide a comprehensive review of Hepatitis E virus in solid-organ transplant patients.
To summarize current knowledge on HEV diagnosis, natural history, clinical features, and treatment strategies.

Main Methods:

Literature review of HEV in solid-organ transplant recipients.
Synthesis of data on diagnosis, clinical course, and therapeutic interventions.

Main Results:

Chronic HEV infection and cirrhosis are significant concerns in immunosuppressed transplant patients.
Diagnostic assays for HEV are not universally accessible.
Reduction of immunosuppression and ribavirin are key therapeutic approaches.

Conclusions:

Solid-organ transplant patients are at risk for chronic HEV infection with potential for cirrhosis.
Effective management strategies for HEV in transplant recipients include diagnostic advancements, immunosuppression modulation, and antiviral therapy.