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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Acral Lentiginous Melanoma.

Melissa Peck Piliang1

  • 1Department of Dermatology and Department of Anatomic Pathology, Cleveland Clinic, Cleveland Clinic Foundation, 9500 Euclid Avenue - A61, Cleveland, OH 44195, USA.

Surgical Pathology Clinics
|February 4, 2016
PubMed
Summary

Acral lentiginous melanoma (ALM) is a rare skin cancer affecting feet and hands, presenting as dark lesions. Histology shows single melanocytes at the junction, requiring differentiation from benign nevi.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Acral lentiginous melanoma (ALM) is an uncommon but aggressive skin malignancy.
  • It affects all races equally and typically presents on the feet or hands.
  • ALM has a poorer prognosis compared to other melanoma subtypes.

Purpose of the Study:

  • To describe the clinical and histological characteristics of acral lentiginous melanoma.
  • To highlight key features for distinguishing ALM from benign acral lentiginous nevi.

Main Methods:

  • Review of clinical presentations of ALM.
  • Histopathological analysis of skin biopsies from ALM lesions.
  • Comparison of histological findings between ALM and benign nevi.
Keywords:
AcralMelanomaNeviPalmsSoles

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Main Results:

  • ALM presents as dark, irregular macules, papules, or nodules on acral skin.
  • Histology is characterized by asymmetric, poorly circumscribed proliferation of single melanocytes at the dermoepidermal junction.
  • Single melanocytes are predominant over nests in ALM.

Conclusions:

  • Acral lentiginous melanoma requires careful histological evaluation.
  • Distinguishing ALM from benign acral lentiginous nevi is crucial due to differences in prognosis and management.
  • Site-related atypia in benign nevi can mimic malignancy.